NF1 Antibody (PACO06677)
- SKU:
- PACO06677
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NF1 Antibody (PACO06677)
The NF1 antibody (PACO06677) is a polyclonal antibody designed for research involving NF1, a tumor suppressor gene associated with neurofibromatosis type 1. This antibody, raised in rabbits, is highly specific and validated for use in various applications including Western blot and immunohistochemistry.NF1 plays a critical role in controlling cell growth and division by inhibiting the Ras signaling pathway. Mutations in the NF1 gene can lead to the development of tumors and other neurological complications. The NF1 antibody enables researchers to detect and analyze NF1 protein expression in various cell types, making it a valuable tool for studying the molecular mechanisms underlying neurofibromatosis type 1 and related disorders.
By understanding the function and regulation of NF1, researchers can uncover potential therapeutic targets for the treatment of neurofibromatosis type 1 and other Ras-related disorders. The NF1 antibody is a key tool for advancing research in this field and expanding our knowledge of the role of NF1 in health and disease.
| Antibody Name: | NF1 Antibody (PACO06677) |
| Antibody SKU: | PACO06677 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human Neurofibromin. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HepG2 cells using Neurofibromin Polyclonal Antibody. |
 | Western Blot analysis of HepG2 cells using Neurofibromin Polyclonal Antibody. |
| Synonyms: | NF1; Neurofibromin; Neurofibromatosis-related protein NF-1 |
| UniProt Protein Function: | NF1: a Ras-GAP, highly expressed in developing neural cells. Possesses tumor suppressor activity, presumably by virtue of its GTPase activating domain. Neurofibromin is phosphorylated in response to EGF in CNS cells and cell lines. Defects in NF1 are the cause of type 1 neurofibromatosis (NF1), Watson syndrome, and familial spinal neurofibromatosis. NF1 is one of the most frequent autosomal dominant diseases. Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Tumor suppressor; GAPs, Ras; GAPs; Nucleolus; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: membrane; axon; dendrite; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; phosphatidylethanolamine binding; phosphatidylcholine binding Biological Process: negative regulation of Rac protein signal transduction; neural tube development; negative regulation of MAP kinase activity; Schwann cell development; extracellular matrix organization and biogenesis; collagen fibril organization; positive regulation of apoptosis; heart development; negative regulation of transcription factor import into nucleus; negative regulation of neuroblast proliferation; regulation of glial cell differentiation; positive regulation of adenylate cyclase activity; negative regulation of neurotransmitter secretion; skeletal muscle development; adrenal gland development; forebrain morphogenesis; negative regulation of cell-matrix adhesion; regulation of synaptic transmission, GABAergic; myelination in the peripheral nervous system; camera-type eye morphogenesis; induction of apoptosis via death domain receptors; negative regulation of fibroblast proliferation; negative regulation of endothelial cell proliferation; negative regulation of protein kinase activity; positive regulation of endothelial cell proliferation; cerebral cortex development; actin cytoskeleton organization and biogenesis; forebrain astrocyte development; metanephros development; regulation of long-term neuronal synaptic plasticity; negative regulation of osteoclast differentiation; phosphoinositide 3-kinase cascade; wound healing; regulation of cell-matrix adhesion; regulation of blood vessel endothelial cell migration; smooth muscle development; sympathetic nervous system development; positive regulation of neuron apoptosis; visual learning; negative regulation of Ras protein signal transduction; cell communication; negative regulation of cell migration; regulation of bone resorption; negative regulation of MAPKKK cascade; MAPKKK cascade; liver development; regulation of angiogenesis; peripheral nervous system development; osteoblast differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of angiogenesis; pigmentation; spinal cord development; negative regulation of astrocyte differentiation; Ras protein signal transduction; response to hypoxia; artery morphogenesis; brain development; cognition Disease: Neurofibromatosis, Familial Spinal; Watson Syndrome; Juvenile Myelomonocytic Leukemia; Neurofibromatosis, Type I; Neurofibromatosis-noonan Syndrome |
| NCBI Summary: | This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21359 |
| NCBI GenInfo Identifier: | 4557793 |
| NCBI Gene ID: | 4763 |
| NCBI Accession: | NP_000258 |
| UniProt Related Accession: | P21359 |
| Molecular Weight: | |
| NCBI Full Name: | neurofibromin isoform 2 |
| NCBI Synonym Full Names: | neurofibromin 1 |
| NCBI Official Symbol: | NF1Â Â |
| NCBI Official Synonym Symbols: | WSS; NFNS; VRNFÂ Â |
| NCBI Protein Information: | neurofibromin |
| UniProt Protein Name: | Neurofibromin |
| UniProt Synonym Protein Names: | Neurofibromatosis-related protein NF-1 |
| Protein Family: | Neurofibromin |
| UniProt Gene Name: | NF1Â Â |
| UniProt Entry Name: | NF1_HUMAN |
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