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NF-kB p65/RelA Polyclonal Antibody (CAB21593)

SKU:
CAB21593
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
$155 - $431
Frequently bought together:

Description

NF-kB p65/RelA Polyclonal Antibody (CAB21593)

The NF-kB p65/RELA Polyclonal Antibody (CAB21593) is a valuable tool for researchers studying the NF-kB signaling pathway, a key regulator of immune and inflammatory responses. This antibody, raised in rabbits, is highly specific for the NF-kB p65/RELA protein and has been validated for use in various applications such as Western blotting.The NF-kB p65/RELA protein is essential for the activation of NF-kB transcription factor complexes, which play a crucial role in the regulation of genes involved in immune and inflammatory responses. Dysregulation of the NF-kB signaling pathway has been implicated in a variety of diseases, including cancer, inflammatory disorders, and autoimmune conditions.

By using the NF-kB p65/RELA Polyclonal Antibody (CAB21593), researchers can accurately detect and analyze the NF-kB p65/RELA protein in a variety of cell types, providing valuable insights into the mechanisms underlying immune and inflammatory responses. This antibody is a valuable tool for studies in immunology, cancer research, and other fields where NF-kB signaling is of interest.

Product Name:NF-kB p65/RelA Polyclonal Antibody
Product Code:CAB21593
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:2000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:NIH/3T3
Cellular Location:Cytoplasm, Nucleus

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 450-551 of human NF-kB p65/RelA (NP_068810.3).
Sequence:LGALL GNSTD PAVFT DLASV DNSEF QQLLN QGIPV APHTT EPMLM EYPEA ITRLV TGAQR PPDPA PAPLG APGLP NGLLS GDEDF SSIAD MDFSA LLSQI SS
Synonyms:p65, CMCU, NFKB3, AIF3BL3
Calculated MW:60kDa
Observed MW:65kDa

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