The Neuropilin-1 Rabbit Monoclonal Antibody (CAB19087) is a high-quality research tool designed for the study of Neuropilin-1, a cell surface receptor with multiple functions in development and disease. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting, immunofluorescence, and immunohistochemistry applications.Neuropilin-1 is known to play a crucial role in a variety of cellular processes, including angiogenesis, axon guidance, and immune regulation. Its involvement in these pathways makes it a promising target for research in cancer, neurological disorders, and immunology.
By using this antibody to detect and analyze Neuropilin-1 expression in different cell types, researchers can gain valuable insights into its function and potential therapeutic applications.Overall, the Neuropilin-1 Rabbit Monoclonal Antibody (CAB19087) serves as a valuable tool for investigating the role of Neuropilin-1 in various biological processes and diseases, paving the way for advancements in both basic science and clinical research.
Product Name:
Neuropilin-1 (NRP1) Rabbit Monoclonal Antibody
SKU:
CAB19087
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Neuropilin-1 (NRP1) (O14786).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
103kDa
Observed MW:
140kDa
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.
Purification Method:
Affinity purification
Gene ID:
8829
Clone Number:
ARC0488
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Neuropilin-1 (NRP1) Rabbit mAb (CAB19087) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
