The NRP1 Polyclonal Antibody (CAB16697) is a valuable tool for researchers studying Neuropilin-1 (NRP1), a cell surface receptor involved in a wide range of biological processes, including angiogenesis, axon guidance, and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.NRP1 is known for its role in promoting tumor growth and metastasis, making it a promising target for cancer research. It also plays a crucial role in the development of the cardiovascular and nervous systems, making it relevant for studies in developmental biology.
By binding specifically to NRP1, this antibody enables the detection and analysis of the receptor in various cell types, making it an essential tool for studies in immunology, oncology, and neurobiology.A deeper understanding of NRP1 function is essential for developing targeted therapies for cancer and other diseases where NRP1 dysregulation is implicated. The NRP1 Polyclonal Antibody provides researchers with a reliable way to investigate the role of NRP1 in health and disease, paving the way for new treatment options and advancements in biomedical research.
Product Name:
Neuropilin-1 (NRP1) Rabbit Polyclonal Antibody
SKU:
CAB16697
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Neuropilin-1 (NRP1) (NP_003864.5).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
103kDa
Observed MW:
120kDa
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.
Purification Method:
Affinity purification
Gene ID:
8829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Neuropilin-1 (NRP1) antibody (CAB16697) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
