The Neurokinin-1 Receptor Rabbit Monoclonal Antibody (CAB4676) is a valuable tool for research involving the neurokinin-1 receptor (NK-1R), a key player in the regulation of pain and inflammation. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunohistochemistry.The NK-1R is a G protein-coupled receptor that binds the neuropeptide substance P, helping to transmit pain signals and modulate inflammatory responses. Its role in pain perception and neuroinflammation makes it a promising target for drug development in pain management and inflammatory disorders.
The CAB4676 antibody enables the detection and analysis of NK-1R expression in different cell types and tissues, allowing researchers to study its function in various physiological and pathological conditions.By understanding the mechanisms of NK-1R signaling, researchers can uncover potential therapeutic strategies for chronic pain, neuroinflammatory diseases, and other conditions where NK-1R dysregulation plays a role. The CAB4676 antibody provides a reliable tool for investigating the role of NK-1R in health and disease, paving the way for the development of novel treatments targeting this important receptor.
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
Purification Method:
Affinity purification
Gene ID:
6869
Clone Number:
ARC1088
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Neurokinin 1 Receptor (NK1R) (NK1R) Rabbit mAb (CAB4676) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
