The Neurogranin Polyclonal Antibody (CAB8444) is a valuable tool for researchers studying neurogranin, a key protein involved in synaptic plasticity and memory formation in the brain. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Neurogranin is a calcium-binding protein found in the brain that plays a crucial role in regulating the strength of synaptic connections, a process essential for learning and memory. Dysregulation of neurogranin levels has been implicated in various neurological disorders, making it a promising target for further research in the field of neuroscience.
By specifically binding to neurogranin, this antibody enables accurate detection and analysis of the protein in various cell types, making it an ideal tool for investigating the molecular mechanisms underlying synaptic plasticity and memory consolidation. Researchers in the fields of neuroscience and neurology will find the Neurogranin Polyclonal Antibody to be an invaluable resource in their studies.
Product Name:
NRGN Rabbit Polyclonal Antibody
SKU:
CAB8444
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human NRGN (NP_001119653.1).
Sequence:
MDCC TENA CSKP DDDI LDIP LDDP GANA AAAK IQAS FRGH MARK KIKS GERG RKGP GPGG PGGA GVAR GGAG GGPS GD
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
Purification Method:
Affinity purification
Gene ID:
4900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NRGN antibody (CAB8444) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
