NFASC Rabbit Polyclonal Antibody (CAB3053)
- SKU:
- CAB3053
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | NFASC Rabbit Polyclonal Antibody |
SKU: | CAB3053 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2). |
Sequence: | RFRV RQPN LETI NLEW DHPE HPNG IMIG YTLK YVAF NGTK VGKQ IVEN FSPN QTKF TVQR TDPV SRYR FTLS ARTQ VGSG EAVT EESP APPN EATP TAAP PTLP PTTV GATG AVSS TDAT AIAA TTEA TTVP IIPT VAPT TIAT TTTV ATTT TTTA AATT TTES PPTT TSGT KIHE SAPD EQSI WNVT VLPN SKWA NITW KHNF GPGT DFVV EYID SNHT KKTV PVKA QAQP IQLT DLYP GMTY TLRV YSRD NEGI SSTV ITFM TSTA YTN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NF; NRCAML; NEDCPMD; NFASC |
Positive Sample: | SH-SY5Y,HeLa,HL-60,Mouse brain,Mouse pancreas,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 150kDa |
Observed MW: | 150kDa |
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 23114 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |