The NeuroD2 Polyclonal Antibody (PAC021862) is a valuable tool for researchers studying the NeuroD2 protein, a key regulator of neuronal development and function. This antibody, produced in rabbits, demonstrates high specificity for human samples and has been validated for use in various applications, including Western blotting.NeuroD2 is a transcription factor that plays a critical role in the differentiation and maturation of neurons in the central nervous system. It is involved in processes such as neuronal migration, dendrite formation, and synaptic plasticity, making it an important target for research in neurobiology and neurodevelopmental disorders.
By specifically binding to the NeuroD2 protein, this antibody enables researchers to detect and analyze its expression in different cell types and tissues. Understanding the function and regulation of NeuroD2 can provide insights into mechanisms underlying neurological diseases such as epilepsy, autism, and neurodegenerative disorders.Overall, the NeuroD2 Polyclonal Antibody is a versatile tool for investigating the role of NeuroD2 in brain development and function, as well as its potential implications in neurological disorders.
Antibody Name:
NEUROD2 Antibody (PACO21862)
Antibody SKU:
PACO21862
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human NDF2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen The MGC Project Team, Genome Res. 14:2121-2127(2004).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, Jurkat cells and 293 cells, using NDF2 antibody.
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
NCBI Summary:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]
