The NeuroD2 Monoclonal Antibody (PAC01162) is a valuable tool for researchers studying NeuroD2, a transcription factor involved in neuronal development and function. This antibody, produced using cutting-edge technology, offers high specificity and sensitivity when detecting NeuroD2 in various samples. It is suitable for use in applications such as Western blot, immunofluorescence, and immunohistochemistry.NeuroD2, also known as Neuronal Differentiation 2, plays a crucial role in the regulation of neuronal differentiation and maturation, making it a key player in the development of the nervous system.
Dysregulation of NeuroD2 has been linked to neurological disorders such as epilepsy, autism, and schizophrenia, highlighting its importance in neuronal health and function.By utilizing the NeuroD2 Monoclonal Antibody, researchers can further explore the functions and mechanisms of NeuroD2 in both normal and diseased states, ultimately advancing our understanding of neurodevelopmental processes and potentially identifying novel therapeutic targets for neurological conditions. This antibody is a valuable addition to any neurobiology or neuroscience research toolkit.
Antibody Name:
NEUROD2 Antibody
Antibody SKU:
PACO01162
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Neuro D2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NEUROD2; BHLHA1; NDRF; Neurogenic differentiation factor 2; NeuroD2; Class A basic helix-loop-helix protein 1; bHLHa1; NeuroD-related factor; NDRF
UniProt Protein Function:
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
NCBI Summary:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]
