The NEURL1 Polyclonal Antibody (PAC005699) is a powerful tool for researchers studying the NEURL1 protein, which plays a key role in neural development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NEURL1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in neuroscience and developmental biology.NEURL1 is a critical regulator of neural development, influencing processes such as neuronal differentiation and synaptic plasticity. Dysregulation of NEURL1 has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.
By investigating the function of NEURL1, researchers can gain valuable insights into the mechanisms underlying neural disorders and potentially develop novel treatment strategies.In summary, the NEURL1 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of NEURL1 in neural development and neurological disorders. Its high reactivity and specificity make it an essential component for advancing our understanding of the intricate processes governing the nervous system.
Antibody Name:
NEURL1 Antibody (PACO05699)
Antibody SKU:
PACO05699
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Neuralized-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67
UniProt Protein Function:
NEURL1: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; Ubiquitin ligase; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Cell development/differentiation; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 10q25.1Cellular Component: dendritic spine; perikaryon; plasma membrane; postsynaptic densityMolecular Function: translation factor activity, non-nucleic acid binding; ubiquitin-protein ligase activityBiological Process: negative regulation of cell proliferation; negative regulation of Notch signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of filopodium formation; positive regulation of long-term neuronal synaptic plasticity; protein monoubiquitination
