The Neurexin 3 Polyclonal Antibody (CAB10269) is a valuable tool for researchers studying Neurexin 3, a cell adhesion protein crucial for synaptic function in the brain. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the Neurexin 3 protein, researchers can effectively detect and analyze its expression in various cell types, making it a versatile tool for neuroscience and neurobiology studies.Neurexin 3 plays a critical role in mediating synaptic transmission and connectivity in the brain, making it a key player in neurological disorders and conditions such as autism spectrum disorders and schizophrenia.
Studying the function of Neurexin 3 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies for patients. With its high reactivity and specificity, the Neurexin 3 Polyclonal Antibody is an essential tool for researchers exploring the role of Neurexin 3 in brain function and neurological diseases.
Product Name:
NRXN3 Rabbit Polyclonal Antibody
SKU:
CAB10269
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 373-432 of human NRXN3 (NP_620426.2).
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder.
Purification Method:
Affinity purification
Gene ID:
9369
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NRXN3 antibody (CAB10269) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
