The Netrin Receptor DCC Polyclonal Antibody (CAB9372) is a valuable tool for researchers studying the Netrin receptor DCC, a protein involved in the guidance of axon growth and cell migration. This antibody, produced in rabbits, is highly specific for detecting the Netrin receptor DCC in human samples and has been validated for use in Western blot applications.The Netrin receptor DCC is known to play a crucial role in the development of the nervous system, as well as in processes such as angiogenesis and tumor progression. By targeting the Netrin receptor DCC, researchers can gain valuable insights into how this protein functions in various cellular processes, making it an essential tool for studies in neuroscience and cancer biology.
With its high reactivity and specificity, the Netrin Receptor DCC Polyclonal Antibody (CAB9372) is a reliable reagent for detecting and analyzing the Netrin receptor DCC in a variety of cell types, providing important information for understanding its role in both normal development and disease. Researchers interested in exploring the functions of the Netrin receptor DCC in different biological contexts will find this antibody to be a valuable asset in their research endeavors.
Product Name:
DCC Rabbit Polyclonal Antibody
SKU:
CAB9372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Not found
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human DCC (NP_005206.2).
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Purification Method:
Affinity purification
Gene ID:
1630
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using DCC Rabbit pAb (CAB9372) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 300s.
