DCC Rabbit Polyclonal Antibody (CAB9372)
- SKU:
- CAB9372
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | DCC Rabbit Polyclonal Antibody |
SKU: | CAB9372 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Not found |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human DCC (NP_005206.2). |
Sequence: | ISGD RLTH QIMD LNLD TMYY FRIQ ARNS KGVG PLSD PILF RTLK VEHP DKMA NDQG RHGD GGYW PVDT NLID RSTL NEPP IGQM HPPH GSVT PQKN SNLL V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1; DCC |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 158kDa |
Observed MW: | 158kDa |
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Purification Method: | Affinity purification |
Gene ID: | 1630 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |