The Neto2 Polyclonal Antibody (PACO10822) is a valuable tool for researchers studying Neto2, a protein involved in synaptic function and plasticity in the brain. This antibody is produced in rabbits and is highly reactive with human samples, making it an ideal choice for studies in neuroscience and neurobiology.Neto2 is a critical regulator of synaptic transmission and plasticity, playing a role in the formation and maintenance of synaptic connections in the brain. Dysregulation of Neto2 has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.
The Neto2 Polyclonal Antibody binds specifically to the Neto2 protein, allowing for accurate detection and analysis in a variety of cell types and tissues. Its validation for use in Western blot applications ensures reliable results, making it a valuable tool for researchers seeking to better understand the role of Neto2 in synaptic function and neurological disorders.
neuropilin (NRP) and tolloid (TLL)-like 2;NETO2;FLJ10430;FLJ14724;FLJ90456;NEOT2 ;
UniProt Protein Function:
NETO2: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 16q11Cellular Component: kainate selective glutamate receptor complex; postsynaptic densityMolecular Function: ionotropic glutamate receptor binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
