| UniProt Protein Function: | NETO1: a transmembrane protein and component of the N-methyl-D-aspartate receptor (NMDAR) complex. Required to maintain the normal level of NMDAR subunits at synapses. The NMDAR complex is a major excitatory ligand-gated ion channel in the central nervous system and a major mediator of synaptic plasticity. Important in the development and/or maintenance of neuronal circuitry. Neto1-deficient mice have a dramatic decrease in the number of NMDA receptors at synapses, impairing learning and synaptic plasticity. Three isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are retina-specific whereas isoform 3 is found in retina as well as at lower levels in adult and fetal brain.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 18q22.2Cellular Component: postsynaptic membrane; kainate selective glutamate receptor complex; postsynaptic density; extracellular region; excitatory synapse; cell junctionMolecular Function: ionotropic glutamate receptor bindingBiological Process: regulation of long-term neuronal synaptic plasticity; visual learning; memory |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q8TDF5 |
| NCBI GenInfo Identifier: | 319918840 |
| NCBI Gene ID: | 81832 |
| NCBI Accession: | NP_001188394.1 |
| UniProt Secondary Accession: | Q8TDF5,Q86W85, Q8ND78, Q8TDF4 |
| UniProt Related Accession: | Q8TDF5 |
| Molecular Weight: | 60,060 Da |
| NCBI Full Name: | neuropilin and tolloid-like protein 1 isoform 3 |
| NCBI Synonym Full Names: | neuropilin (NRP) and tolloid (TLL)-like 1 |
| NCBI Official Symbol: | NETO1Â Â |
| NCBI Official Synonym Symbols: | BCTL1; BTCL1Â Â |
| NCBI Protein Information: | neuropilin and tolloid-like protein 1; brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 |
| UniProt Protein Name: | Neuropilin and tolloid-like protein 1 |
| UniProt Synonym Protein Names: | Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 |
| Protein Family: | |
| UniProt Gene Name: | NETO1Â Â |
| UniProt Entry Name: | NETO1_HUMAN |
