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Nesprin3 Rabbit mAb (CAB21164)

SKU:
CAB21164
Product Type:
Antibody
Host Species:
Rabbit
Size:
20uL, 100uL
Isotype:
IgG
  • Nesprin3 Rabbit mAb (CAB21164)
  • Nesprin3 Rabbit mAb (CAB21164)
€159 - €419
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Description

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Nesprin3 Rabbit mAb (CAB21164)

The Nesprin3 Rabbit Monoclonal Antibody (CAB21164) is a high-quality antibody specifically designed for research involving Nesprin3, a key protein involved in maintaining cytoskeletal organization and nuclear positioning within cells. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity for detecting Nesprin3 in various cell types and tissues.Nesprin3 is known to play a critical role in nuclear positioning and anchoring, as well as in regulating cellular structure and function. Dysregulation of Nesprin3 has been implicated in various diseases, including muscular dystrophy and cancer.

By targeting Nesprin3 with this antibody, researchers can gain valuable insights into its functions and its potential roles in disease development.This antibody is optimized for use in various applications such as Western blot, immunofluorescence, and immunohistochemistry, providing researchers with a versatile tool for studying Nesprin3 in different experimental settings. Its reliability and consistency make it an essential reagent for studies focused on understanding the role of Nesprin3 in cellular biology and disease pathology.

Product Name: Nesprin3 Rabbit mAb
SKU: CAB21164
Size: 20uL, 100uL
Isotype: IgG
Clone Number: ARC3013
Host Species: Rabbit
Reactivity: Human, Mouse
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 750-935 of human Nesprin3 (NP_689805.3).
Sequence: LIRN WHLQ RMEV DSGK KMVF TNNI PKSG FLIN PMDP IPRH RRRR ANLL QEEE GSH EDFS QLLR NFGQ WLQV ENSK LVR IIA MRTS TAED LRTR KSKL QELE ARVP EGQH LFEN LLRL GPAR GTS DELL EDLR YQWM LYSK LKDS GHLL TQSS PGEP TGFQ KTRR WRGL GSLF RRAC CCVA LPLQ LLLL
Tested Applications: WBELISA
Recommended Dilution: WB: 1:500 - 1:1000
Synonyms: KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341; Nesprin3
Positive Sample: HeLa, Jurkat, Mouse spleen
Conjugate: Unconjugated
Cellular Localization: Nucleus envelope,Nucleus outer membrane,Rough endoplasmic reticulum,Single-pass type IV membrane protein.
Calculated MW: 112kDa
Observed MW: 112kDa

Enables actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Involved in cytoskeleton organization; establishment of protein localization to membrane; and regulation of cell shape. Located in nuclear membrane. Part of meiotic nuclear membrane microtubule tethering complex. Biomarker of Huntington's disease.

Purification Method: Affinity purification
Gene ID: 161176
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product Image CAB21164 Western blot analysis of various lysates, using Nesprin3 Rabbit mAb (CAB21164) at1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (AbGn00020).
Exposure time: 60s.
Product Image CAB21164 Western blot analysis of lysates from Mouse spleen, using Nesprin3 Rabbit mAb (CAB21164) at1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (AbGn00021).
Exposure time: 60s.

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