The NEK5 Polyclonal Antibody (PAC019208) is a valuable tool for researchers studying NEK5, a protein kinase involved in regulating cell cycle progression and mitosis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to NEK5, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it ideal for research in cell biology and cancer biology.NEK5 is an important player in cell division, controlling processes such as chromosome segregation and cytokinesis.
Dysregulation of NEK5 has been linked to abnormalities in cell cycle progression, leading to conditions such as cancer. Investigating the function of NEK5 is essential for understanding its role in disease development and progression, and may lead to the identification of potential therapeutic targets for cancer treatment.Overall, the NEK5 Polyclonal Antibody offers researchers a reliable tool for studying the function and regulation of NEK5 in cellular processes, with implications for advancing our understanding of cancer biology and potentially identifying novel therapeutic strategies.
Antibody Name:
NEK5 Antibody (PACO19208)
Antibody SKU:
PACO19208
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human NEK5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19208(NEK5 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO19208(NEK5 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Nek5 (NimA-related protein kinase 5) is a 708 amino acid, protein that is related to NIMA, a protein that was originally discovered in Aspergillus nidulans and is necessary for entry into mitosis. One of several members of the Set/Thr protein kinase super family, Nek5 contains one protein kinase domain through which it catalyzes the ATP-dependent phosphorylation of target proteins. Like NIMA, Nek5 may be involved in mitotic regulation and cell cycle control.
