NEK3 Rabbit Polyclonal Antibody (CAB6665)
- SKU:
- CAB6665
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | NEK3 Rabbit Polyclonal Antibody |
SKU: | CAB6665 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-506 of human NEK3 (NP_689933.1). |
Sequence: | PEII MEYG EEVL EEIK NSKH NTPR KKTN PSRI RIAL GNEA STVQ EEEQ DRKG SHTD LESI NENL VESA LRRV NREE KGNK SVHL RKAS SPNL HRRQ WEKN VPNT ALTA LENA SILT SSLT AEDD RGGS VIKY SKNT TRKQ WLKE TPDT LLNI LKNA DLSL AFQT YTIY RPGS EGFL KGPL SEET EASD SVDG GHDS VILD PERL EPGL DEED TDFE EEDD NPDW VSEL KKRA GWQG LCDR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HSPK36; NEK3 |
Positive Sample: | MCF7,HL-60,THP-1,HepG2,HeLa,Mouse kidney,Rat kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, axon. |
Calculated MW: | 58kDa |
Observed MW: | 55kDa |
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon.
Purification Method: | Affinity purification |
Gene ID: | 4752 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |