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NEK11 Antibody (PACO39162)

SKU:
PACO39162
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • NEK11 Antibody PACO39162
  • NEK11 Antibody PACO39162
$407

Description

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NEK11 Antibody (PACO39162)

The NEK11 Polyclonal Antibody (PAC039162) is a valuable tool for researchers studying NEK11, a protein involved in cell cycle regulation and DNA damage response. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used in Western blot applications with human samples. By targeting NEK11, this antibody allows for the detection and analysis of the protein in various cell types, making it a suitable choice for investigations in cancer and cell biology research.NEK11 is a key player in cell division processes, acting as a regulator of mitotic entry and centrosome duplication.

Its involvement in DNA damage repair pathways also highlights its importance in maintaining genomic stability. Research on NEK11 is particularly relevant in the context of cancer, where aberrant cell cycle regulation and DNA repair mechanisms can contribute to tumorigenesis and tumor progression.By utilizing the NEK11 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of NEK11 in cellular processes, ultimately advancing our understanding of its role in cancer biology and potential therapeutic applications.

Antibody Name:NEK11 Antibody (PACO39162)
Antibody SKU:PACO39162
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: NEK11 antibody at 7µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75, 55, 56, 69 kDa. Observed band size: 75 kDa.
Product ImageImmunohistochemistry of paraffin-embedded human testis tissue using PACO39162 at dilution of 1:100.
Background:Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Synonyms:Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11), NEK11
UniProt Protein Function:NEK11: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Interacts with isoform 1 of NEK2. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; NEK familyChromosomal Location of Human Ortholog: 3q22.1Cellular Component: nucleolus; nucleoplasmMolecular Function: ATP binding; protein binding; protein serine/threonine kinase activityBiological Process: G2/M transition DNA damage checkpoint; histone phosphorylation; intra-S DNA damage checkpoint; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
UniProt Code:Q8NG66
NCBI GenInfo Identifier:313104142
NCBI Gene ID:79858
NCBI Accession:Q8NG66.2
UniProt Secondary Accession:Q8NG66,Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4, A6NHD7
UniProt Related Accession:Q8NG66
Molecular Weight:68,880 Da
NCBI Full Name:Serine/threonine-protein kinase Nek11
NCBI Synonym Full Names:NIMA related kinase 11
NCBI Official Symbol:NEK11  
NCBI Official Synonym Symbols:
NCBI Protein Information:serine/threonine-protein kinase Nek11
UniProt Protein Name:Serine/threonine-protein kinase Nek11
UniProt Synonym Protein Names:Never in mitosis A-related kinase 11; NimA-related protein kinase 11
Protein Family:
UniProt Gene Name:NEK11  
UniProt Entry Name:NEK11_HUMAN
Antibodies
NEK11 Antibody (PACO10814)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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