The NEIL1 Polyclonal Antibody (CAB5828) is a valuable tool for researchers studying NEIL1, a DNA glycosylase enzyme involved in base excision repair. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the NEIL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in DNA repair mechanisms and oxidative stress-related diseases.NEIL1 plays a crucial role in maintaining genomic stability by correcting oxidative DNA damage, which can lead to mutations and contribute to the development of various diseases, including cancer and neurodegenerative disorders.
By understanding the function and regulation of NEIL1, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.Overall, the NEIL1 Polyclonal Antibody (CAB5828) serves as a valuable tool for researchers investigating DNA repair pathways and the impact of oxidative damage on cellular health. Its specificity and reliability make it an essential resource for studies aimed at unraveling the molecular mechanisms of disease and developing targeted treatments.
Product Name:
NEIL1 Rabbit Polyclonal Antibody
SKU:
CAB5828
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human NEIL1 (NP_078884.2).
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79661
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse spleen, using NEIL1 antibody (CAB5828) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
