Neurofilament M Rabbit Monoclonal Antibody (CAB19085)
The NEFM Rabbit Monoclonal Antibody (CAB19085) is a vital tool for research involving NEFM, a crucial protein found in neurofilaments that provide structural support for nerve cells in the brain and spinal cord. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting NEFM in human samples, making it a reliable choice for experiments such as Western blotting and immunohistochemistry.NEFM, also known as neurofilament medium chain, is essential for the functioning of nerve cells and is involved in various neurological disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).
By utilizing this antibody to study NEFM expression and localization in different cell types and tissues, researchers can gain valuable insights into the role of neurofilaments in neurodegenerative diseases and neuronal development.The NEFM Rabbit Monoclonal Antibody (CAB19085) is a versatile tool with the potential to advance our understanding of neurobiology and contribute to the development of targeted therapies for neurological conditions. Its high quality and reliability make it an invaluable asset for scientists conducting research in the fields of neuroscience and neurology.
Product Name:
Neurofilament M Rabbit Monoclonal Antibody
SKU:
CAB19085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human Neurofilament M (P07197).
Sequence:
ELVA DAKV EKPE KAKS PVPK SPVE EKGK SPVP KSPV EEKG KSPV PKSP VEEK GKSP VPKS PVEE KGKS PVSK SPVE EKAK SPVP KSPV EEAK SKAE VGKG E
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
4741
Clone Number:
ARC0396
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Neurofilament M Rabbit mAb (CAB19085) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
