Neurofilament M Rabbit Polyclonal Antibody (CAB16405)
The NEFM Polyclonal Antibody (CAB16405) is a valuable tool for researchers studying the neurofilament medium protein (NEFM), a key component of the neuronal cytoskeleton. This antibody, produced in rabbits, is highly specific and is validated for use in various applications, including immunohistochemistry and western blotting.NEFM is essential for maintaining the structural integrity of neurons and plays a crucial role in neuronal development and function. Dysregulation of NEFM has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).
By using the NEFM Polyclonal Antibody, researchers can accurately monitor NEFM expression levels in different cell types and tissues, facilitating insights into the pathophysiology of these diseases.Furthermore, the NEFM Polyclonal Antibody can also be used in studies investigating neurodegeneration, axonal transport, and synaptic plasticity. Its high specificity and sensitivity make it an indispensable tool for researchers seeking to unravel the complex mechanisms underlying neuronal function and dysfunction.
Product Name:
Neurofilament M Rabbit Polyclonal Antibody
SKU:
CAB16405
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human Neurofilament M (NP_005373.2).
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
4741
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using Neurofilament M Rabbit pAb (CAB16405) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
