Neurofilament L Rabbit Polyclonal Antibody (CAB0257)
- SKU:
- CAB0257
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Neurofilament L Rabbit Polyclonal Antibody |
SKU: | CAB0257 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L (NP_006149.2). |
Sequence: | SSGS LMPS LENL DLSQ VAAI SNDL KSIR TQEK AQLQ DLND RFAS FIER VHEL EQQN KVLE AELL VLRQ KHSE PSRF RALY EQEI RDLR LAAE DATN EKQA LQGE REGL EETL RNLQ ARYE EEVL SRED AEGR LMEA RKGA DEAA LARA ELEK RIDS LMDE ISFL KKVH EEEI AELQ AQIQ YAQI SVEM DVT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; Neurofilament L |
Positive Sample: | 293T,SH-SY5Y,U-251MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | axon, axon cytoplasm, cholinergic synapse, cytoplasm, cytosol, growth cone, neurofilament, neuromuscular junction, postsynaptic intermediate filament cytoskeleton, presynaptic intermediate filament cytoskeleton, Schaffer collateral - CA1 synapse |
Calculated MW: | 62kDa |
Observed MW: | 70kDa |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Purification Method: | Affinity purification |
Gene ID: | 4747 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |