Neurofilament H Rabbit Polyclonal Antibody (CAB8442)
The NEFH Polyclonal Antibody (CAB8442) is a valuable tool for research involving the neurofilament heavy chain (NEFH), a key structural protein in neurons. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By specifically binding to NEFH, this antibody enables precise detection and analysis of the protein in different neuronal cell types.NEFH is essential for maintaining the structural integrity of neurons and plays a crucial role in neuronal development and function. Dysregulation of NEFH has been linked to various neurodegenerative diseases, making it a promising target for research in neurology and neuroscience.
Understanding the functions and regulation of NEFH is vital for gaining insights into the mechanisms underlying these diseases and developing potential therapeutic interventions.Researchers in the field of neuroscience, neurology, and neurodegenerative disorders can benefit from the use of the NEFH Polyclonal Antibody (CAB8442) to further their studies and contribute to advancements in the understanding and treatment of neurological conditions.
Product Name:
Neurofilament H Rabbit Polyclonal Antibody
SKU:
CAB8442
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 873-1020 of human Neurofilament H (NP_066554.2).
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
Purification Method:
Affinity purification
Gene ID:
4744
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Neurofilament H Rabbit pAb (CAB8442) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
