Neurofilament H Rabbit Polyclonal Antibody (CAB8442)
- SKU:
- CAB8442
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Neurofilament H Rabbit Polyclonal Antibody |
SKU: | CAB8442 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 873-1020 of human Neurofilament H (NP_066554.2). |
Sequence: | KVEE KKEP AVEK PKES KVEA KKEE AEDK KKVP TPEK EAPA KVEV KEDA KPKE KTEV AKKE PDDA KAKE PSKP AEKK EAAP EKKD TKEE KAKK PEEK PKTE AKAK EDDK TLSK EPSK PKAE KAEK SSST DQKD SKPP EKAT EDKA AKGK |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | NFH; CMT2CC; Neurofilament H |
Positive Sample: | Mouse brain,Mouse liver,Rat brain,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | axon, cytoplasm, cytoskeleton, neurofilament, postsynaptic density, postsynaptic intermediate filament cytoskeleton, Schaffer collateral - CA1 synapse |
Calculated MW: | 112kDa |
Observed MW: | 150kDa/220kDa |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
Purification Method: | Affinity purification |
Gene ID: | 4744 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |