The NEDD8 Monoclonal Antibody is a powerful tool for researchers studying the NEDD8 protein, an important regulator of protein degradation and cell cycle progression. This antibody, derived from mouse cells, is highly specific and reliable for use in various applications such as Western blotting and immunofluorescence.NEDD8 is a small ubiquitin-like modifier that plays a key role in the ubiquitin-proteasome pathway, where it activates and regulates the activity of cullin-RING ligases. Dysregulation of NEDD8 signaling has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions.
By using the NEDD8 Monoclonal Antibody, researchers can gain insights into the function of NEDD8 in different cellular processes and disease states. This antibody is an essential tool for studies aiming to understand the molecular mechanisms underlying protein degradation and cell cycle control, with implications for drug development and personalized medicine.
Product Name:
NEDD8 Monoclonal Antibody
SKU:
CAB22568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human NEDD8 (NP_006147.1).
Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma.
Purification Method:
Affinity purification
Gene ID:
4738
Clone Number:
ARC58460
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NEDD8 antibody (CAB22568) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 150s.
