NEDD4L Rabbit Polyclonal Antibody (CAB8085)
- SKU:
- CAB8085
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | NEDD4L Rabbit Polyclonal Antibody |
SKU: | CAB8085 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 836-955 of human NEDD4L (NP_056092.2). |
Sequence: | GDVD VNDW RQHS IYKN GYCP NHPV IQWF WKAV LLMD AEKR IRLL QFVT GTSR VPMN GFAE LYGS NGPQ LFTI EQWG SPEK LPRA HTCF NRLD LPPY ETFE DLRE KLLM AVEN AQGF EGVD |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2; NEDD4L |
Positive Sample: | BT-474,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 112kDa |
Observed MW: | 113kDa |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 23327 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |