The Nectin-2 Polyclonal Antibody (CAB5378) is a valuable tool for researchers studying the Nectin-2 protein, which plays a key role in cell adhesion and signaling pathways. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the Nectin-2 protein, researchers can accurately detect and analyze its expression in various cell types.Nectin-2, also known as CD112, is a cell adhesion molecule that is involved in the formation of cell-cell junctions and the regulation of immune responses. Its function in immune signaling makes it an important target for studies in immunology, cancer research, and inflammatory diseases.
By studying Nectin-2, researchers can gain valuable insights into its role in disease progression and immune system function, leading to potential therapeutic interventions.Overall, the Nectin-2 Polyclonal Antibody (CAB5378) is a reliable tool for researchers looking to explore the function and significance of Nectin-2 in various biological processes. Its high specificity and sensitivity make it an asset for studies aiming to uncover the mechanisms underlying diseases related to cell adhesion and immune regulation.
Product Name:
Nectin 2/CD112 Rabbit Polyclonal Antibody
SKU:
CAB5378
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 382-479 of human Nectin 2/CD112 (NP_002847.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
72kDa
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
5819
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Nectin 2/CD112 antibody (CAB5378) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
