The Nectin-2 (CD112) Rabbit Monoclonal Antibody (CAB9622) is a valuable tool for researchers studying Nectin-2, a cell adhesion molecule that plays a role in cell-cell interactions and immune responses. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By specifically binding to the Nectin-2 protein, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in immunology and cancer research.
Nectin-2, also known as CD112, is involved in mediating cell adhesion and immune responses, making it a key player in immune regulation and inflammatory processes. Its significance in modulating immune function positions it as an important target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of Nectin-2 is crucial for the development of therapies that modulate immune responses and improve treatment outcomes in these disease contexts.
Product Name:
Nectin 2/CD112 Rabbit Monoclonal Antibody
SKU:
CAB9622
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 410-538 of human Nectin 2/CD112 (ARC1665).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
72kDa
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
5819
Clone Number:
ARC1665
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Nectin 2 Rabbit mAb (CAB9622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
