PVRL1 Rabbit Polyclonal Antibody (CAB2037)
- SKU:
- CAB2037
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PVRL1 Rabbit Polyclonal Antibody |
SKU: | CAB2037 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-517 of human PVRL1 (NP_002846.3). |
Sequence: | ERKV GGPH PKYD EDAK RPYF TVDE AEAR QDGY GDRT LGYQ YDPE QLDL AENM VSQN DGSF ISKK EWYV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1 |
Positive Sample: | BT-474,HepG2,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Secreted, Single-pass type I membrane protein, presynaptic cell membrane, synapse. |
Calculated MW: | 57kDa |
Observed MW: | 55kDa |
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Purification Method: | Affinity purification |
Gene ID: | 5818 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |