The Nectin-1 Polyclonal Antibody (CAB2037) is a valuable tool for research involving Nectin-1, a cell adhesion molecule involved in various biological processes such as cell adhesion, migration, and signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the Nectin-1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and cancer research.
Nectin-1, also known as CD111, is a key player in cell-cell adhesion and communication, playing a crucial role in the maintenance of tissue structure and function. Dysregulation of Nectin-1 has been implicated in various diseases, including cancer, viral infections, and neurological disorders. Research into the function and regulation of Nectin-1 is essential for understanding its role in disease pathology and may lead to the development of targeted therapies in the future.
Product Name:
PVRL1 Rabbit Polyclonal Antibody
SKU:
CAB2037
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-517 of human PVRL1 (NP_002846.3).
Cell junction, Cell membrane, Secreted, Single-pass type I membrane protein, presynaptic cell membrane, synapse.
Calculated MW:
57kDa
Observed MW:
55kDa
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Purification Method:
Affinity purification
Gene ID:
5818
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PVRL1 antibody (CAB2037) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
