The NECAP1 Polyclonal Antibody (PAC010804) is an essential tool for researchers studying NECAP1, a protein involved in clathrin-dependent endocytosis and synaptic vesicle recycling. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for Western blotting and other immunological techniques. By targeting the NECAP1 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating investigations in neuroscience and cell biology.
NECAP1 plays a crucial role in regulating endocytic pathways and synaptic vesicle trafficking, making it a key player in neuronal function and neurotransmitter release. Its involvement in these processes underscores its importance in understanding neurodegenerative diseases, such as Alzheimer's and Parkinson's. By unraveling the mechanisms of NECAP1, researchers can uncover new therapeutic targets and interventions for these conditions, ultimately leading to potential breakthroughs in the field of neurology.
NECAP1: Involved in endocytosis. Belongs to the NECAP family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 12p13.31Cellular Component: clathrin vesicle coat; plasma membrane; coated pitBiological Process: protein transport; endocytosisDisease: Epileptic Encephalopathy, Early Infantile, 21
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
