The NECAB3 Polyclonal Antibody (CAB15500) is a valuable tool for researchers studying NECAB3, a neuron-specific calcium-binding protein involved in calcium signaling and neurotransmitter release. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting NECAB3 in human samples, making it suitable for use in various research applications such as Western blotting.NECAB3 is known to play a crucial role in regulating synaptic transmission and plasticity in the brain, making it a promising target for studies on neurological disorders and neurodegenerative diseases.
Its expression pattern and function suggest potential implications in conditions such as Alzheimer's disease, Parkinson's disease, and epilepsy. By utilizing the NECAB3 Polyclonal Antibody, researchers can explore the molecular mechanisms underlying these diseases and potentially identify new therapeutic strategies.
Product Name:
NECAB3 Rabbit Polyclonal Antibody
SKU:
CAB15500
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-362 of human NECAB3 (NP_112508.3).
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
63941
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NECAB3 Rabbit pAb (CAB15500) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
