The NEBL Antibody (PACO59812) is a key tool for researchers studying the NEBL gene, which encodes the protein nebulette involved in regulating muscle contraction and relaxation. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the NEBL protein, this antibody enables precise detection and analysis in a variety of cell types, making it essential for investigations in cardiology and muscle biology.NEBL, a crucial component of the sarcomere in cardiac and skeletal muscle, plays a vital role in maintaining muscle structure and function.
Dysregulation of NEBL expression has been linked to various cardiovascular diseases and muscle disorders, highlighting its importance in cardiovascular and muscle research. The NEBL Antibody provides valuable insights into the function and regulation of NEBL, aiding in the development of potential therapies for cardiovascular conditions and muscle-related disorders.
Immunofluorescence staining of PC-3 cells with PACO59812 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.
