The NDUFV2 Polyclonal Antibody (CAB7442) is a valuable tool for researchers studying the NDUFV2 protein, a critical component of the mitochondrial respiratory chain complex I. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot analyses. By targeting the NDUFV2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent tool for studies in mitochondrial biology and related fields.The NDUFV2 protein is essential for the function of complex I in the electron transport chain, which is crucial for ATP production and cellular energy metabolism.
Dysregulation of complex I function has been linked to various human diseases, including neurodegenerative disorders and metabolic diseases. Therefore, understanding the role of NDUFV2 in complex I activity is essential for elucidating the molecular mechanisms underlying these conditions and developing potential therapeutic interventions.Overall, the NDUFV2 Polyclonal Antibody (CAB7442) offers researchers a reliable tool for investigating the function of the NDUFV2 protein and its involvement in mitochondrial biology, providing valuable insights into cellular energy metabolism and potential disease pathways.
Product Name:
NDUFV2 Rabbit Polyclonal Antibody
SKU:
CAB7442
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human NDUFV2 (NP_066552.2).
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19.
Purification Method:
Affinity purification
Gene ID:
4729
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NDUFV2 antibody (CAB7442) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
