The NDUFV1 Polyclonal Antibody (CAB13333) is a valuable tool for researchers studying NDUFV1, a critical component of the mitochondrial membrane respiratory chain complex I. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the NDUFV1 protein, this antibody enables the detection and analysis of NDUFV1 in various cell types, making it ideal for research in bioenergetics and mitochondrial function.NDUFV1 is essential for the production of ATP, the primary energy source for cells, and any dysregulation of its function can lead to mitochondrial dysfunction and various diseases, including neurodegenerative disorders and metabolic syndromes.
Understanding the role of NDUFV1 in mitochondrial function is crucial for developing therapies targeting mitochondrial dysfunction and improving cellular energy production.Overall, the NDUFV1 Polyclonal Antibody (CAB13333) is a valuable tool for researchers studying mitochondrial function and energy metabolism, offering reliable and specific detection of NDUFV1 in a variety of research applications.
Product Name:
NDUFV1 Rabbit Polyclonal Antibody
SKU:
CAB13333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NDUFV1 (NP_009034.2).
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
4723
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDUFV1 Rabbit pAb (CAB13333) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
