The NDUFs7 Polyclonal Antibody is a reliable tool for researchers studying NDUFs7, a subunit of mitochondrial complex I involved in electron transport and oxidative phosphorylation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to NDUFs7, this antibody enables the detection and analysis of this crucial protein in various cell types, facilitating research in bioenergetics and mitochondrial function.NDUFs7 is essential for the proper functioning of mitochondrial complex I, the largest enzyme complex in the respiratory chain responsible for generating ATP. Dysregulation of complex I activity has been linked to various mitochondrial disorders, neurodegenerative diseases, and cancer.
Therefore, studying NDUFs7 is crucial for understanding the molecular mechanisms underlying these conditions and developing potential therapeutic strategies targeting mitochondrial function.Overall, the NDUFs7 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of NDUFs7 in cellular metabolism, energy production, and disease pathogenesis. Its high specificity and performance in Western blot assays make it a reliable reagent for unraveling the complex biology of mitochondrial complex I and its implications in human health and disease.
Product Name:
NDUFS7 Polyclonal Antibody
SKU:
CAB24466
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 80-160 of human NDUFS7 (NP_077718.3).
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions.
Purification Method:
Affinity purification
Gene ID:
374291
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NDUFS7 Rabbit pAb (CAB24466) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
