The NDUFS6 Polyclonal Antibody (CAB3985) is a valuable tool for researchers studying the NDUFS6 protein, a critical component of complex I in the electron transport chain. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and has been validated for use in Western blot applications.The NDUFS6 protein is essential for the proper function of complex I, the first enzyme complex in the electron transport chain that plays a crucial role in cellular energy production. Mutations in NDUFS6 have been linked to various mitochondrial diseases and neurodegenerative disorders, making it an important target for research in the fields of genetics, biochemistry, and neurology.
By using the NDUFS6 Polyclonal Antibody, researchers can accurately detect and analyze NDUFS6 protein levels in a variety of cell types, allowing for deeper insights into the role of this protein in normal cellular function and disease pathology. This antibody is a valuable tool for studies investigating mitochondrial dysfunction, energy metabolism, and the development of potential therapies for mitochondrial disorders.
Product Name:
NDUFS6 Rabbit Polyclonal Antibody
SKU:
CAB3985
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-124 of human NDUFS6 (NP_004544.1).
This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.
Purification Method:
Affinity purification
Gene ID:
4726
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NDUFS6 antibody (CAB3985) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
