The NDUFS1 Polyclonal Antibody (CAB16926) is specifically designed for research involving NDUFS1, a subunit of the mitochondrial enzyme complex I that plays a crucial role in the electron transport chain. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NDUFS1 protein, it allows for the detection and analysis of NDUFS1 in various cell types, making it an essential tool for studies in metabolism, bioenergetics, and mitochondrial dysfunction.NDUFS1 is essential for the proper functioning of complex I in the electron transport chain, which is responsible for generating the majority of ATP in cells.
Dysregulation of NDUFS1 has been linked to various metabolic disorders, neurodegenerative diseases, and mitochondrial dysfunction. Studying NDUFS1 is critical for gaining a better understanding of these conditions and developing targeted therapeutic interventions.In summary, the NDUFS1 Polyclonal Antibody (CAB16926) is a valuable resource for researchers investigating the role of NDUFS1 in cellular metabolism and mitochondrial function. Its high specificity and sensitivity make it a reliable tool for advancing knowledge in the fields of biochemistry, molecular biology, and mitochondrial research.
Product Name:
NDUFS1 Rabbit Polyclonal Antibody
SKU:
CAB16926
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human NDUFS1 (NP_004997.4).
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4719
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDUFS1 Rabbit pAb (CAB16926) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
