The NDUFB9 Polyclonal Antibody (CAB17454) is a valuable tool for researchers investigating the NDUFB9 protein, a critical component of the mitochondrial respiratory chain complex I. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to NDUFB9, this antibody enables the detection and analysis of the protein in various cell types, making it an ideal choice for studies in mitochondrial biology and energy metabolism.NDUFB9 is essential for the function of complex I in the electron transport chain, playing a key role in the generation of ATP through oxidative phosphorylation.
Dysregulation of NDUFB9 has been linked to various diseases, including metabolic disorders and neurological conditions. By understanding the role of NDUFB9 in mitochondrial function, researchers can gain insights into the pathogenesis of these diseases and potentially identify new therapeutic targets for treatment. The NDUFB9 Polyclonal Antibody is a valuable tool for advancing research in this field and uncovering the complexities of mitochondrial biology.
Product Name:
NDUFB9 Rabbit Polyclonal Antibody
SKU:
CAB17454
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-170 of human NDUFB9 (NP_004996.1).
The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4715
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDUFB9 Rabbit pAb (CAB17454) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
