The NDUFB6 Polyclonal Antibody (PAC010789) is a valuable tool for researchers studying NDUFB6, a protein component of the mitochondrial respiratory chain complex I. This antibody, generated in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to NDUFB6, the antibody allows for the detection and analysis of this protein in a variety of cell types, making it an ideal choice for studies related to mitochondrial function and cellular metabolism.NDUFB6 is essential for the function of complex I in the electron transport chain, playing a crucial role in cellular energy production.
Dysregulation of NDUFB6 has been implicated in various diseases, including mitochondrial disorders and certain types of cancer. Therefore, investigating the role of NDUFB6 in mitochondrial function is essential for understanding the pathophysiology of these conditions and developing targeted therapies. The NDUFB6 Polyclonal Antibody is a valuable tool for researchers interested in exploring the molecular mechanisms involving NDUFB6 and its implications in human health.
NDUFB6: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFB6 subunit family.Protein type: Energy Metabolism - oxidative phosphorylation; EC 1.6.5.3; Oxidoreductase; Membrane protein, integral; EC 1.6.99.3; MitochondrialChromosomal Location of Human Ortholog: 9p21.1Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; mitochondrial membrane; integral to membrane; mitochondrial respiratory chain complex IMolecular Function: NADH dehydrogenase (ubiquinone) activityBiological Process: cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]
