NDUFAF3 Antibody (PACO59437)
- SKU:
- PACO59437
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NDUFAF3 Antibody (PACO59437)
The NDUFAF3 Polyclonal Antibody (PAC05937) is a valuable tool for researchers studying NDUFAF3, a protein involved in mitochondrial complex I assembly and function. This antibody, produced in rabbits, is highly specific for detecting NDUFAF3 in human samples and has been validated for use in Western blot applications. By targeting NDUFAF3, researchers can investigate its role in mitochondrial function and its potential implications in diseases related to mitochondrial dysfunction, such as neurodegenerative disorders and metabolic diseases.
The NDUFAF3 Polyclonal Antibody is an essential tool for studies aiming to uncover the molecular mechanisms underlying mitochondrial complex I assembly and its impact on cellular health.
| Antibody Name: | NDUFAF3 Antibody (PACO59437) |
| Antibody SKU: | PACO59437 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human NADH dehydrogenase [ubiquinone] 1 α subcomplex assembly factor 3 protein (91-184AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59437 diluted at 1:100 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO59437 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). |
| Synonyms: | NADH dehydrogenase [ubiquinone] 1 α subcomplex assembly factor 3, NDUFAF3, C3orf60 |
| UniProt Protein Function: | NDUFAF3: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Defects in NDUFAF3 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 3p21.31Cellular Component: mitochondrial inner membrane; nucleusMolecular Function: protein bindingBiological Process: mitochondrial respiratory chain complex I assemblyDisease: Mitochondrial Complex I Deficiency |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2009] |
| UniProt Code: | Q9BU61 |
| NCBI GenInfo Identifier: | 74733183 |
| NCBI Gene ID: | 25915 |
| NCBI Accession: | Q9BU61.1 |
| UniProt Secondary Accession: | Q9BU61 |
| UniProt Related Accession: | Q9BU61 |
| Molecular Weight: | 13,842 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase complex assembly factor 3 |
| NCBI Official Symbol: | NDUFAF3Â Â |
| NCBI Official Synonym Symbols: | 2P1; E3-3; C3orf60Â Â |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | NADH dehydrogenase |
| UniProt Gene Name: | NDUFAF3Â Â |
| UniProt Entry Name: | NDUF3_HUMAN |
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