Anti-NDUFA6 Antibody (CAB9831)
- SKU:
- CAB9831
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-NDUFA6 Antibody (CAB9831)
The NDUFA6 Polyclonal Antibody (CAB9831) is a valuable tool for researchers studying the NDUFA6 protein, a critical component of the mitochondrial respiratory chain complex I. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.The NDUFA6 protein plays a key role in electron transfer and ATP production within the mitochondria, making it essential for cellular energy metabolism. Dysregulation of NDUFA6 has been linked to a variety of metabolic disorders and mitochondrial dysfunction-related diseases, making it a promising target for therapeutic intervention.
By using the NDUFA6 Polyclonal Antibody, researchers can accurately detect and analyze NDUFA6 levels in various cell types, shedding light on its function and potential role in disease development. This antibody is a valuable tool for studies in biochemistry, metabolism, and mitochondrial biology, offering insights that may lead to new treatment strategies for related disorders.
| Antibody Name: | Anti-NDUFA6 Antibody |
| Antibody SKU: | CAB9831 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-154 of human NDUFA6 (NP_002481.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, HepG2, 22Rv1, Mouse kidney, Mouse heart, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-154 of human NDUFA6 (NP_002481.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATST ASTF VKPI FSRD MNEA KRRV RELY RAWY REVP NTVH QFQL DITV KMGR DKVR EMFM KNAH VTDP RVVD LLVI KGKI ELEE TIKV WKQR THVM RFFH ETEA PRPK DFLS KFYV GHDP |
| Gene ID: | 4700 |
| Uniprot: | P56556 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Calculated MW: | 17kDa |
| Observed MW: | 13kDa |
| Synonyms: | NDUFA6, B14, CI-B14, LYRM6, NADHB14 |
| Background: |
| UniProt Protein Function: | NDUFA6: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I LYR family. |
| UniProt Protein Details: | Protein type:EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; EC 1.6.99.3 Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: mitochondrial inner membrane; mitochondrial membrane; mitochondrial respiratory chain complex I Molecular Function:NADH dehydrogenase (ubiquinone) activity Biological Process: cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; response to oxidative stress |
| UniProt Code: | P56556 |
| NCBI GenInfo Identifier: | 51317370 |
| NCBI Gene ID: | 4700 |
| NCBI Accession: | NP_002481.2 |
| UniProt Secondary Accession: | P56556,O43675, Q6FGW0, Q6IBT8, Q6IC39, B2RE54, |
| UniProt Related Accession: | P56556 |
| Molecular Weight: | 17,871 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase subunit A6 |
| NCBI Official Symbol: | NDUFA6Â Â |
| NCBI Official Synonym Symbols: | B14; LYRM6; CI-B14; NADHB14Â Â |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 |
| UniProt Synonym Protein Names: | Complex I-B14; CI-B14; LYR motif-containing protein 6; NADH-ubiquinone oxidoreductase B14 subunit |
| Protein Family: | NADH dehydrogenase |
| UniProt Gene Name: | NDUFA6Â Â |
| UniProt Entry Name: | NDUA6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NDUFA6 antibody (CAB9831) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using NDUFA6 antibody (CAB9831) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using NDUFA6 antibody (CAB9831) at dilution of 1:100 (40x lens). |
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