The NDUFA2 Polyclonal Antibody (CAB8136) is a vital tool for researchers studying NDUFA2, a subunit of mitochondrial complex I involved in electron transport and energy production. This antibody, generated in rabbits, is highly specific to NDUFA2 in human samples and has been validated for use in Western blot applications. By binding to the NDUFA2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential asset for research in mitochondrial biology and related fields.NDUFA2 is a key component of mitochondrial complex I, essential for the generation of ATP through oxidative phosphorylation. Dysregulation of NDUFA2 has been implicated in various diseases, including neurodegenerative disorders and metabolic syndromes.
Understanding the function and regulation of NDUFA2 is crucial for unraveling the mechanisms underlying these pathologies and for developing potential therapeutic interventions targeting mitochondrial dysfunction.The NDUFA2 Polyclonal Antibody (CAB8136) offers researchers a reliable tool for studying the role of NDUFA2 in cellular metabolism, energy production, and disease progression. Its high specificity and sensitivity make it ideal for use in a wide range of experimental settings, facilitating in-depth investigations into the molecular mechanisms governing mitochondrial function and dysfunction.
Product Name:
NDUFA2 Rabbit Polyclonal Antibody
SKU:
CAB8136
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human NDUFA2 (NP_002479.1).
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDUFA2 Rabbit pAb (CAB8136) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
