The NDRG1 Rabbit Monoclonal Antibody (CAB4050) is a valuable tool for researchers studying NDRG1, a protein involved in regulating cell growth, differentiation, and stress responses. This high-quality antibody, produced in rabbits, demonstrates strong reactivity with human samples and has been validated for use in Western blot applications.NDRG1, also known as N-myc downstream-regulated gene 1, plays a crucial role in various cellular processes, including cell cycle regulation, DNA repair, and metastasis suppression. Dysregulation of NDRG1 has been linked to cancer progression and other diseases, highlighting its importance in biological research.
By targeting the NDRG1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for immunology and cancer research studies. Understanding the function and regulation of NDRG1 can provide valuable insights into disease mechanisms and potential therapeutic targets, ultimately leading to advancements in the treatment of cancer and other related conditions.
Product Name:
NDRG1 Rabbit Monoclonal Antibody
SKU:
CAB4050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 295-394 of human NDRG1 (Q92597).
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
10397
Clone Number:
ARC0887
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NDRG1 Rabbit mAb (CAB4050) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
