The NDNL2 Antibody (PAC019226) is a high-quality polyclonal antibody designed for research involving NDNL2, a protein involved in DNA repair processes and cell cycle regulation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the NDNL2 protein, enabling accurate detection and analysis in various cell types, making it an ideal tool for studies in molecular biology and cancer research.
NDNL2 is a critical player in maintaining genomic stability and is involved in repairing DNA damage, making it a key target for understanding cancer development and progression. Its role in cell cycle regulation also suggests potential implications in other diseases characterized by abnormal cell growth and division. Research into NDNL2 can provide valuable insights into disease mechanisms and potential therapeutic strategies targeting DNA repair pathways.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19226(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse liver tissue, A172 cells, human prostate tissue, Primary antibody: PACO19226(NDNL2 Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19226(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
Synonyms:
necdin-like 2
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
