The NDE1 Polyclonal Antibody (CAB7112) is a valuable tool for researchers studying NDE1, a protein involved in neurodevelopment and cell division. This antibody, raised in rabbits, has a high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the NDE1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in neuroscience and developmental biology.
NDE1 is known to play a critical role in the regulation of mitotic spindle organization and centrosome function, making it a key player in neuronal development and cell division. Understanding the mechanisms of NDE1 is essential for unraveling the complexities of neurodevelopmental disorders and cancer. By targeting NDE1 with this polyclonal antibody, researchers can gain valuable insights into the function of this protein and its implications in various diseases.
Product Name:
NDE1 Rabbit Polyclonal Antibody
SKU:
CAB7112
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human NDE1 (NP_060138.1).
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
54820
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDE1 Rabbit pAb (CAB7112) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
