Anti-HEC1 Antibody (CAB2392)
- SKU:
- CAB2392
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Anti-HEC1 Antibody (CAB2392)
The HEC1 Rabbit Monoclonal Antibody (CAB2392) is a cutting-edge tool for researchers studying the HEC1 protein, which plays a vital role in mitosis and cell division. This antibody, developed using rabbit monoclonal technology, offers high specificity and sensitivity for detecting HEC1 in various research applications, such as immunofluorescence and immunohistochemistry.HEC1 is a key component of the kinetochore, a protein complex essential for proper chromosome segregation during cell division. Dysregulation of HEC1 has been linked to chromosome instability and cancer development, making it a promising target for cancer research and drug development.
By using the HEC1 Rabbit Monoclonal Antibody, researchers can gain insights into the function and regulation of HEC1 in cellular processes, paving the way for advancements in understanding cancer biology and potential therapeutic interventions.Overall, the HEC1 Rabbit Monoclonal Antibody is a valuable tool for researchers seeking to explore the role of HEC1 in mitosis, cell division, and cancer progression. Its high specificity and sensitivity make it an excellent choice for studies aimed at unraveling the complexities of this essential protein.
| Antibody Name: | Anti-HEC1 Antibody |
| Antibody SKU: | CAB2392 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HEC1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | A synthesized peptide derived from human HEC1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10403 |
| Uniprot: | O14777 |
| Cellular Location: | |
| Calculated MW: | 74kDa |
| Observed MW: | 76KDa |
| Synonyms: | HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 |
| Background: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
| UniProt Protein Function: | HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O14777 |
| NCBI GenInfo Identifier: | 74735330 |
| NCBI Gene ID: | 10403 |
| NCBI Accession: | O14777.1 |
| UniProt Secondary Accession: | O14777,Q6PJX2, |
| UniProt Related Accession: | O14777 |
| Molecular Weight: | 73,913 Da |
| NCBI Full Name: | Kinetochore protein NDC80 homolog |
| NCBI Synonym Full Names: | NDC80, kinetochore complex component |
| NCBI Official Symbol: | NDC80Â Â |
| NCBI Official Synonym Symbols: | HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80Â Â |
| NCBI Protein Information: | kinetochore protein NDC80 homolog |
| UniProt Protein Name: | Kinetochore protein NDC80 homolog |
| UniProt Synonym Protein Names: | Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC |
| Protein Family: | Kinetochore protein |
| UniProt Gene Name: | NDC80Â Â |
| UniProt Entry Name: | NDC80_HUMAN |
 | Western blot - HEC1 Rabbit mAb (CAB2392) |
Related Products
HEC1/NDC80 Rabbit Polyclonal Antibody (CAB5411)
CD274 Monoclonal Antibody (CAB23922)
IFN gamma Monoclonal Antibody (CAB23929)
Anti-CREB1 Antibody (CAB11063)
Anti-NUR77 Antibody (CAB0843)
Anti-HDAC6 Antibody (CAB11429)
