The ND5 Polyclonal Antibody (CAB8135) is a crucial tool for research involving ND5, a subunit of complex I in the mitochondrial respiratory chain. This antibody, developed in rabbits, exhibits a high specificity for human samples and is validated for use in Western blot applications. By binding to the ND5 protein, this antibody enables the detection and analysis of ND5 in various cell types, making it ideal for studies in mitochondrial function and energy metabolism.ND5, a key player in the electron transport chain, plays a vital role in ATP production and cellular respiration. Dysregulation of ND5 has been linked to various diseases, including mitochondrial disorders and neurodegenerative conditions.
Research into the function and regulation of ND5 is essential for understanding the mechanisms underlying these disorders and developing potential therapies.The ND5 Polyclonal Antibody provides researchers with a valuable tool for studying the expression and function of ND5 in different biological contexts. Its specificity and sensitivity make it a reliable choice for investigating the role of ND5 in mitochondrial function and its implications for human health.
Product Name:
MT-ND5 Rabbit Polyclonal Antibody
SKU:
CAB8135
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-607 of mouse MT-ND5 (NP_904338.1).
Contributes to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in central nervous system; heart; liver; metanephros; and retina. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5).
Purification Method:
Affinity purification
Gene ID:
17721
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MT-ND5 Rabbit pAb (CAB8135) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
