The NCS1 Polyclonal Antibody (CAB13586) is a valuable tool for researchers studying NCS1, a neuronal calcium sensor protein involved in various cellular processes, including neurotransmitter release and synaptic plasticity. This antibody, produced through rabbit immunization, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the NCS1 protein, this antibody enables researchers to detect and analyze NCS1 expression in different cell types, making it a versatile choice for neuroscience and neurology studies.NCS1, also known as frequenin, is a key player in calcium signaling pathways within neurons, impacting neurotransmission and neuronal excitability.
Dysfunction in NCS1 has been linked to neurological disorders such as schizophrenia, bipolar disorder, and Parkinson's disease, highlighting its importance in brain function and disease pathology. By elucidating the role of NCS1 in these conditions, researchers can pave the way for potential therapeutic interventions targeting this protein.In conclusion, the NCS1 Polyclonal Antibody (CAB13586) offers researchers a reliable tool for investigating the function and implications of NCS1 in neurological processes and disorders. Its specificity and sensitivity make it a valuable asset for enhancing our understanding of neuronal calcium signaling and its impact on brain health.
Product Name:
NCS1 Rabbit Polyclonal Antibody
SKU:
CAB13586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human NCS1 (NP_055101.2).
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NCS1 antibody (CAB13586) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
